Scientific documents library

The intended objective of this article is to highlight the importance of early detection of chronic kidney disease (CKD). The diagnosis of CKD often requires the input of many disciplines alongside that of the primary health caregiver. It is common for patients with CKD to also have other chronic conditions, including but not restricted to hypertension, diabetes, and cardiovascular disease.

Abnormal RBC results generate extra workload for laboratories and require careful interpretation to guide treatment options. This white paper describes common RBC diseases, both acquired and hereditary, that are frequently encountered in a routine laboratory, and presents how intelligent interpretation of blood counts and algorithms can help identifying these conditions. Subsequent confirmatory tests lead to improved turn-around times.

This white paper focuses on the different phases of a haematopoietic stem cell transplantation, the challenges faced by clinicians during the process. Focus is put on how advanced clinical parameters from Sysmex haematology analysers can support the clinician with valuable additional information over these phases. The parameters that can assist are: in the assessment of patients during chemotherapy (L-WBC mode, PLT-F, EIP), stem cell mobilisation (HPC) and stem cell engraftment (IRF, IPF).

Sysmex Educational Enhancement and Development April 2015 The importance of statistical investigations

A deeper insight about an activation of the immune response of patients can be acquired from newly available diagnostic parameters that support differentiation between inflammation and infection, different pathogenic causes of infection (viral versus bacterial) and different types of immune response: early innate, cellular or humoral immune response.

The Blood Bank mode (BB mode) is an optional mode for blood product measurement and quantification of residual cells left in the manufactured blood products. The front side of the lab information card gives an overview of blood component analysis and explains the benefit of the BB mode. The flip side presents information about sample types, technological requirements, workflow enhancements and specifications of the mode.

Platelets are normally measured by impedance, but when interferences are present, this may lead to a wrong count. There are alternatives methods for platelet measurement that are here explained in detailed, like the fluorescence flow cytometry and the accurate count provided by the PLT-F channel.

In this case report a blood test was requested for a male patient during a routine check-up, which appeared mostly normal. However, the WDF scattergram presented all WBC subpopulations with very low fluorescence signals appearing in the bottom end of the scattergram and the analyser triggered the flag ‘WBC Abn Scattergram’. A follow-up HPLC analysis revealed the mildly unstable haemoglobin variant ‘Hb G-Ferrara’.

Sysmex Educational Enhancement and Development April 2012